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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e1278095db330b0079429c942f2c2ec1fc1aa8a29e5e82169203a1be208fb480' 
  AND token = 'iObPPgyTitmNwmy4MXxR92sjN5LFqk9e4tTSkZI11u0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}