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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5266d4f4f5698a2e9b8a47f2855b42093659d60f1cd1a852299dc4e25fbce852' 
  AND token = 'zTdw2/cXnwthSHwoA/YtPPMnc5hRhNfcJgObvsZxfEA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}