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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '26e452ad821ce4ee419c7a1782b8222630a6a37efae8a3b08cb2ab1ec9ebb265' 
  AND token = 'VK2VvVk1JDZNmW2bWqUwrWKWBtmYdieB3a/FJ+Ff2/8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}