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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '25019fc53f2918c31df4083c1fc3cb00f6ba5253038efd21d87d2b3f59e19d0a' 
  AND token = 'UO8uLqqzjEy3bUQeXd6vjfwqFoDiJbj2ihO2W8UQRd8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}