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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '246c25a4a78fd516e226b7f1e3128b663fb28a048c14da105ae9e342e859c45a' 
  AND token = 'yQJYhuNU7bkPOk74aBvv1QMCxR+pRCRxvdOjCD7pUhk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}