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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e26d0615aa86276ef3d601ee4b7e368894f727ccad96e8c6a135e2d2bc8169e4' 
  AND token = 'hU+tuJLutw9Cs/u45QHhNwSOHHZM5sJUiyH6Onn7VHI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}