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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5df1a6b2e6782bd2fc7de7c01121e159946cd548c41ce6198f4a944ac3a07010' 
  AND token = 'SUqzkktmCoy5Nnj9eEZsdKXQZpVtBzTBINn7agio9Xs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}