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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2d730601db4e9265f36f0d07c379f4014052bf433659c51016208c5f5915e3bc' 
  AND token = 'w6MSiVHVGuA+GRbT54pAZQfCKyoN8gKwZF/0VrM6Ghc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}