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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2b563945f51624ea55b4f6daeb243e2d6151366861e13cd2186770d331d0a2e2' 
  AND token = 'dW/9E/b65RVrFBFclGHryNqPzd0pZTOkD/ZSaB4GHew=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}