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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2afdf74513a451812ba5135bbe98bfc1b4da045393b4e5b873028975ec329274' 
  AND token = '64jdi5KFJlWi4995myRcm+wb0twUra7l/9ZBVzQmOmE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}