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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '750279db456563f8e0d6f360fb4a9c9f63e6825d6257574d3f7fec75415d8d10' 
  AND token = 'OZLrflbLIQSDfkaZnKBfI8L8lPxUsVrAQ6nVfYin6P0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}