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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '445cb6901d69e4a91606a12c6c78a3c9d5c49f7b3bcc81212163e5a88091e515' 
  AND token = '8yA6k4UfD9FvmUwFcvkVrlYLx0N5ZcJlMSnKBKMHNwo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}