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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '54451aea0e3dcf1d88f47cb34e503896080d9f4aa2a552ce0e04233be4b30364' 
  AND token = 'Ib/b5FXQo7A0nPIHkE3aUKTaMKw9CM6N10AMGI6zacA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}