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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '53d0f9c9a1f557191acf88fd4ba86ba9159866e543ce2b4745734323501295bd' 
  AND token = '+Kx6S73eKNpRhcF981dhnhNYpZi+8pQ4XTpwkML+0mA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}