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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6f5538afe2083fc8ea9ccfaeb5191aa251549160006f614a276ea84fde0bd538' 
  AND token = 'R6xRmeaJdxFHtfMNmY+BBs9GyHC4PbAqx+VxFFKKWnc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}