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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6ccb33c6fe52e42424c4450218e091f6a0701693538a305e8423273a4fb9845f' 
  AND token = 'JFwWw2HR0C8KtSoFDKTnp+ACIInXpD8k7dXM0zB6Xt0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00031

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}