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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ec21bb47c3e6348661ff05b00443496540f4f0fd3c0a46f93f88207eaa4cd8f7' 
  AND token = '8Jgc/9BJE0NfNnC+2PO/TVOfEW/oplyvN/ZJ6FiRe3c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}