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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e44d6c144bb5c73c4e122ebe70445d44e97357f3fcf49540db079c06e738943d' 
  AND token = 'm0EEJdydP6Ju17uCq+Uqvh34vquFdmi1wJbjaNWr3Bs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}