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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '404b1468798c16a56b90fb0ff9f175f0438c114137f04a4204db81a01a5cb491' 
  AND token = 'Bhbb+K6JTcAeiaw3lHiqvo89PNIcZCHnnvUH5sR4ez0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}