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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2e8a7e4b78b02b3caef8d2e202b11703538de7747d6c2a825d71908d9e782df6' 
  AND token = 'A0ZEoELGwqiPM6zyBfVZI9Sv1SpKE3ATH475Xji/rK4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}