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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7a78f6bfedebb8e675b96625d472150e7e6b9506c54cc7023a449242a2d57240' 
  AND token = 'uc0vmV9cAYGW+M/GsnBtZU6JK0DihHhu2pXWdY14Sts=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}