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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '72ee27f31e0f7ef4427c2fab72344a00ecb78348b48465ef1571e8caf4b3b169' 
  AND token = 'Jz1cdFJfAnXiXVtq7nQ6LVZ9lsR6HOZpZUt+YrugZuM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}