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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b271d52eeb09b34d78613a84e71859264693f89c4b9d0718fa980e47ca1b34d8' 
  AND token = 'VUjvK+MhtbmD7FYT0IW5j/s6KetLNjyiktQ9meeTcMU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}