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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b3150c0e12432ee316a8c4146f7ce731946b7b78acf3e018bc8513aac75e446a' 
  AND token = 'OpYIz/Wypcl6qhc+jfv7J6T2E4CcYpNjsLCyJuwPqxw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}