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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c5ad80b95983e4f5f7d11431da77ca5de131dc977e0d3512ede58130e933d09c' 
  AND token = 'PYG4WCXOPKCMM16PAiBUr0eQDCGTbEa+qSgu+zsEpoM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}