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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2def3a39a89d007ee4c3a53e97cf0b3f959476f96b52b3501b4e0a7fb438e768' 
  AND token = 'tQvV4XH/S8GSHEd2AMAIW/4f9K7FSF0WbRXOjGbEi/g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}