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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6e5401dfdcfa0aa5ebd28f6d10f4b3d0067e1219dd6b2903ed4bfa4798363846' 
  AND token = 'iZP6F3Zo2uL96QUXAwBZP3kG2zVYUqmq2RtK7H0VIiA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}