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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8bc1668bcee78255858eb4d6b3d205037487ec6e3a9789041905e7687735e295' 
  AND token = 'cOXxkVMx6fHBXycjLEVrJ9TRg2wVVdEOgTiNzW8UfnI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}