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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '66c6a7cfcd8ad2310827e6be0174a2a299d437860bf8a8c366f7336d89feefa0' 
  AND token = 'ndJM7SNuEe9M1HJq0dPoiVgAxZ1bD052Y+PTOHUkKyY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}