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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f72739daf332f16c31702b331b4b72a97911e42e40490dee6642fd8f99e3a287' 
  AND token = 'u5CEiH2WBmDqHi2E2KK2v5Vr9re/rQ5k5Mz3eTcojx0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}