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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8c2e1e656b18e56d3d6f320560b231c001635c803a8938f89392c1269257fa3e' 
  AND token = 'dJeFG6V/xnmaj//RzHaqEnHM04Q7dfGNBUZ6arYcRlw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}