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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '52a529610e0e45b79a85be290f8bfd539fff9c52f9039b13c4bf50e3f446d139' 
  AND token = 'FzWw4cNg+zPDGQ6HbLzDRUjeO2eeL1zyBvmyunIYq3k=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}