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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '728b45280b9cbece39d0f527f059554d81010756b396ae0b1c2fc2fc06f1e5c2' 
  AND token = '/aoO/rVibRhMuxrSu0CTYheH4nKijrHo1Elze5b9XnU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}