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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6af28985e5323c8fbe8c92ac16ecf8978a29210e2c97e527f184db2af07f9340' 
  AND token = 'EpBBERq2XUnrc5jaCUHA0rbDiyNf6tab+HSLdXU/uBQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}