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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6a592c2d7276c0c2522f03854bd7e1c50e2bc7f1d6d358a038c1b0caf650354b' 
  AND token = 'kUKYKXOjQo1+xsfhF3jOdSTgPqCCwElaWPRmb0l7Fg8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}