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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '75e4438412b95cd7a3a6a616d33e506b88e8a3aa80b4013a908b632e3ca7abca' 
  AND token = 'SbGSlYyXgF+c/TXQWmNKt5vn+42pPi9RK0pTbZS1cc0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}