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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '72187732dc8a58e477bda5ad0f2899eb50828244ae855b469082d6b4535fe086' 
  AND token = '4SW7GrqhsV6yMDJeKtLbReYZj8+JnrNpNJUIPNIM7d0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}