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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '46aedede42bb8b5a52433e135b9ccc46023a1f224258ce3da84b4908763bc49d' 
  AND token = 'mWuM8nTMghbyz76Sc+hT0hfaEyHBG+YOba1GXSgkBpw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00031

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}