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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '100e621eff5b005923669a9ed31caafda83c19796bbde0d656c34e909bfc2cd5' 
  AND token = 'anF9RMIk/XR7j0pHPJOKD9u+PVtjrmKJ+Ip/JhmeTpQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}