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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e33a84b3eaf2888bbf402f4852787387a67e7302cde49d783139980ac99f68a7' 
  AND token = 'ND/wRnErBZxVrEd5HVnm6cj8rwiJNXoU8+/G3NbEc3c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}