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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '466fb41480b71a695d18c0884f04cdd1d82c3ec39a053f0d5938d2e310d6fa33' 
  AND token = '5Lz+rMmikimLF7wQ8EBCKPCENvsLUmDnKkSTQ89cZqw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}