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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0f46cb0b33917a45e522940bc35f4e35f49523ccc8ddeaed155c4894a9d8e298' 
  AND token = 'KodfXVHU/LtlIa2P453j2yuHFtTTrfWCl6WIRO8m/XM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}