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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '499e181a4d6b35e717f3b8ee8e2916d3393b69683b5a9b312e618ed0f828b4ef' 
  AND token = 'MN2q+vjPFWrCxPCa9MsKlCWmzRo7lcaoVhr8wSP0zCo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}