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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '273a606887bccf2fbccf3cb8497644cd80a483586c7b48430e4dadfcec49bd0c' 
  AND token = 'mkyB0VVHcbmKpUImzciYqoCLKOzzRDo3chBHFY0zVM8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}