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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'af1afb8b4915c3aad9b22557b70401f48d36bfd9d6a37b14ad35c10ac13e3176' 
  AND token = 'IFRCHOe74YFXhbyCE0VJbxUhcpmLchIMAZkLw0Nq+UM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}