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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '259d680b80198e3bc17000b69bb4223efb474a9e78fefc6b5c0c13fe2e0f21c6' 
  AND token = 'Twjh+/+HddtSLdpbNre2RzniKB7E2sgv8YTBZrdlUSo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00043

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}