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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '45dbc325c89e2448852c2cd58596df4c74dc6527412d0c4dc200280bf21e8170' 
  AND token = 'DFrTgcuBcZwkKUpeBrvHP9FVPZ4OuVH2i0FflN5CCEE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}