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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4d141ac7f778ed7bc100d25a64b14a6f3f2d2163c7a701795a2ed864ec0220bf' 
  AND token = 'w3/G7qkbfx81T+DUyloB2jdcKdSZdcj2BM4HT1Bcs8o=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}