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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '280fe843c2748a13c0aa2b5aeac2f8981e3d3edc834bce9391b6b587f335f857' 
  AND token = 'S+MJR7/vmti+XvQEklS2+Q2HUbTNG/jw3QXxsmUuUNo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}