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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '391f5bf1e5cdb3518a651cb4cb9a22e01ba40976905d1f4d830aa123cea0e998' 
  AND token = 'VdCFdErIMqI1MeA3c+tnTlBYXJ23NWkWRLqLnJi49NM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}